House, M.D. is ludicrous, but in a different way. House (Hugh Laurie) solves medical mysteries by using some crazy diagnoses and oftentimes through malpractice. It's a VERY interesting show. It's more of a drama, but is still humorous. You should at least watch one episode of it and see if you think it's interesting. If it isn't, then go back to It's Always Sunny. If it is, you just found a great new show to watch.